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Nokia has performed hard work to create a good service and supply new services without delay..Strain-dependent oral administration of microbial supernatant confers protection against Salmonella typhimurium-induced colitis in mice.
Given the strong association between probiotic consumption and decreased risk of colon cancer, there is a growing interest in the therapeutic potential of probiotics in the colon. This study investigated the role of commensal gut bacteria in the oral administration of a probiotic solution against Salmonella typhimurium-induced colitis. Pregnant Swiss Webster mice were orally administered a solution containing Lactobacillus casei Shirota and Bifidobacterium animalis ssp. lactis BB-12. At weaning, the offspring were orally inoculated with S. typhimurium and euthanized 3 d later. Mice that were orally treated with the probiotic solution were partially protected against S. typhimurium infection. However, administration of the probiotic solution did not influence Salmonella colonization in germ-free animals. These findings indicate that oral administration of a probiotic solution prevents bacterial translocation in pregnant mice and provides host protection against S. typhimurium infection in mice. Further studies are warranted to establish the relevant murine model that best mimics human disease and to investigate the specific mechanisms involved.Morphological changes of the human nasal olfactory epithelium at birth.
In the embryonic human nasal cavity the embryonic olfactory epithelium, which develops from the surface ectoderm, exists in direct contact with the amniotic fluid. The epithelium shows a normal morphology and immuno-reactivity with the olfactory marker protein. The olfactory epithelium is in a more mature state than the respiratory epithelium as judged by the densities of receptors (recombinant olfactory marker protein) and transporters (cytochrome P450 2D6) in the olfactory epithelium. For the first time we have been able to show histologically that the o
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